The Use Of Nanotechnology On Other Types Of Brain Cancer

Glioma, a destructive type of brain cancer, and other types of brain diseases have been mostly untreatable due to the blood brain barrier (BBB). There have been drugs produced that are effec-tive in treating these diseases, but simply cannot bypass the barrier due to its special properties. It serves to restrict and control the movement of molecules in and out of the brain. In recent years, the use of nanotechnology show promise with their abilities to bypass the BBB to deliver drugs and small molecules into the brain. Gold nanoparticles (AuNPs) obtained the most interest, as it has been used in earlier applications, and their ability to be tracked by CT imaging or atomic ab-sorption. By first looking at the size of the nanoparticle, researchers were able to decide which size of nanoparticles would have the most AuNP uptake across the BBB. It was found AuNPs less than 50nm are the most ideal for the amount of delivery within brain cells. A precursor prob-lem of reaching the BBB is th e protein corona. It labels AuNPs immediately when it enters the bloodstream for phagocytosis. By adding a hydrophilic surfactant onto these AuNPs, it allows for them to have an increase circulation time in the blood to reach the BBB and into the brain. The option of using adsorptive-mediated transcytosis (AMT) or receptor-mediated transcytosis (RMT) will allow nanoparticles to increase their permability acorss the BBB. By utilizing these techniques, nanoparticles are able to enter the brain withShow MoreRelatedA Search For The Right Cure1069 Words   |  5 PagesI-Search Project: A Search for the Right Cure I know of basic brain cancer treatments such as chemotherapy and tumor removal, but once a brain tumor has been left untreated for an extended period of time, death is usually inescapable. Sometimes even when cured in time, the brain tumor may return later. 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